Chi-Chao Chan M.D. NEI, NIH

at []

1. R.R. Buggage, J.A. Smith, D.F. Shen, C.C. Chan: Conjunctival T-cell lymphoma caused by HTLV-1 infection. Am J Ophthalmol 131:381-383, 2001.
2. N. Tuaillon, C.C. Chan: Molecular analysis of primary central nervous system and primary intraocular lymphoma. Curr Mol Med 1:259-272, 2001.
3. M.D. de Smet, C.C. Chan: Regulation of ocular inflammation - What experimental and human studies have taught us. Prog Ret Res 20:733-759, 2001.
4. N. Cassoux, H. Merle-Beral, V. Leblond, B. Bodaghi, D. Milea, S. Gerber, C. Fardeau, I. Reux, I. Reux, K.H. Xuan, C.C. Chan, P. LeHoang: Ocular and central nervous system lymphoma: clinical features and diagnosis. Ocul Immunol Inflam 8:243-250, 2001.
5. R.R. Buggage, C.C. Chan, R.B. Nussenblatt: Ocular manifestations of CNS lymphoma. Curr Opin Oncol 13:137-142, 2001.
6. G.A. Levy- Clarke, G.A. Byrnes, R.R. Buggage, D.F. Shen, A.C. Filie, R.C. Caruso, R.B. Nussenblatt, C.C. Chan: Primary intraocular lymphoma diagnosed by fine needle aspiration biopsy of a subretinal lesion. Retina 21:281-284, 2001.
7. G. Sosne, C.C. Chan, K. Thai, M. Kennedy, E.A. Szliter, L.D. Hazlett, H.K. Kleinman: Thymosin beta 4 promotes corneal wound healing and modulates inflammatory mediators in vivo. Exp Eye Res 72:605-608, 2001.
8. A.N. Tullio, P.C. Bridgman, N.J. Tresser, C.C. Chan, M.A. Conti, R.S. Adelstein, Y. Hara: Structural abnormalities develop in the brain following ablation of the gene encoding nonmuscle myosin II-B heavy chain. J Compar Neurol 433:62-74, 2001.
9. G. Velez, P. Yuan, C. Sung, G. Tansey, G.F. Reed, C.C. Chan, R.B. Nussenblatt, M.R. Robinson: Pharmacokinetics and toxicity of intravitreal chemotherapy for primary intraocular lymphoma. Arch ophthalmol 119:1518-1524, 2001.
10. N. Cassoux, H. Merle-Beral, P. LeHoang, C. Herbort, C.C. Chan: Interleukin-10 and intraocular-central nervous system lymphoma. Ophthalmology 108:426,2001.
11. G. Lambert, N. Sakai, B.L. Vaisman, E.B. Neufeld, B. Marteyn, C.C. Chan, B. Paigen, E. Lupia, A. Thomas, L.J. Striker, J. Blanchette-Mackie, G. Csako, J.N. Brady, R. Costello, G.E. Striker, A.T. Remaley, H.B. Brewer, Jr., S. Santamarina-Fojo: Analysis of glomerulosclerosis and atherosclerosis inlecithin cholesterol acyltransferase deficient mice. J Biol Chem 276:15090-15098, 2001.
12. G. Velez, C.E. Roy, S.M. Whitcup, C.C. Chan, M.R. Robinson: High-dose intravitreal ganciclovir and foscarnet for cytomegalovirus retinitis. Am J Ophthalmol 131:396-397, 2001.
13. D.F. Shen, D.M. Matteson, N. Tuaillon, B.K. Suedekum, R.R. Buggage, C.C. Chan: Involvement of apoptosis and gamma interferon in murine toxoplasmosis. Invest Ophthalmol Vis Sci 42:2031-2036, 2001.
14. S.B. Su, P.B. Silver, M. Zhang, C.C. Chan, R.R. Caspi: Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals. J Immunol 167:250-256, 2001.
15. M.M. Mozes, J.A. Bryant, R. Franks, C.C. Chan, J.B. Kopp: Congenital nuclear cataracts and uveitis in HIV-transgenic mice. Eye 16:177-184, 2002.
16. D.F. Shen, C.P. Herbort, N. Tuaillon, R.R. Buggage, C.E. Egwuagu, C.C. Chan: Detection of Toxoplasma gondii DNA in primary intraocular B cell lymphomas. Mod Pathol 14:995-999, 2001.
17. S. Lertsumitkul, S.M. Whitcup, C.C. Chan, R.B. Nussenblatt: Subretinal fibrosis in Vogt-Koyanagi-Harada syndrome. Ophthalmology 108:1371, 2001.
18. Q. Li, M.F. Ashhraf, D.F. Shen, W.R. Green, W.J. Stark, C.C. Chan, T.P. O'Brien: The role of apoptosis in the pathogenesis of Fuchs' endothelial dystrophy of the cornea. Arch Ophthalmol 119:1597-1604, 2001.
19. R.R. Buggage, J.A. Smith, D.F. Shen, C.C. Chan: Conjunctival papillomas caused by human papilloma virus type 33. Arch Ophthalmol 120:202-204, 2002.
20. J.A. Smith, C.C. Chan, E. Goldin, R. Schiffmann: Noninvasive diagnosis and ophthalmic features of mucolipidosis type IV. Ophthalmology 109:588-594, 2002.
21. N. Tuaillon, D.F. Shen, R.B. Berger, B. Lu, B.J. Rollins, C.C. Chan: MCP-1 plays a major role in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 43:1493-1498, 2002.
22. C.C. Chan, C.A. Koch, M.I. Kaiser-Kupfer, D.M. Parry, D.H. Gutmann, Z. Zhuang, A.O. Vortmeyer: Loss of heterozygosity for the NF2 gene in retinal and optic nerve lesions of patients with neurofibromatosis 2. J Pathol (in press).
23. G. Adamus, C.C. Chan: Experimental autoimmune uveitides: Multiple antigens, diverse diseases. Int Rev Immunol 21:209-229, 2002.
24. E.F. Foxman, M. Zhang, S. Hurst, T. Muchamuel, D. Shen, C.C. Chan, I. Gery: Inflammatory mediators in uveitis: differential induction of cytokines and chemokines in Th1 vs. Th2-mediated ocular inflammation. J Immunol 168:2483-2492, 2002.
25. S.J. Kim, M. Zhang, B.P. Vistica, C.C. Chan, D.F. Shen, E.F. Wawrousek, I.Gary: Induction of ocular inflammation by T-helper lymphocytes type 2. Invest Ophthalmol Vis Sci 43:758-765, 2002.
26. D.I. Ham, S. Gentleman, C.C. Chan, J.H. McDowell, T.M. Redmond, I. Gery: RPE65 is highly uveitogenic in rats. Invest Ophthalmol Vis Sci 43:2258-63, 2002.
27. V.L. Davis, C.C. Chan, T.J. Schoen, J.F. Couse, G.J. Chader, K.S. Korach: An estrogen receptor repressor induces cataract formation in transgenic mice. Proc Natl Acad Sci 99:9427-9432, 2002.
28. Y. Perntes, C.C. Chan, E. Bovey, S. Uffer, C.P. Herbort: Massive vascular endothelium growth factor (VEGF) expression in Eale's disease. Klin Monatsbl Augenheilkd 219:311-314, 2002.
29. G. Velez, C.C. Chan, K.G. Casky: Fluorescein angiographic findings in primary intraocular lymphoma. Retina 22:37-43, 2002.
30. G. Levy-Clarke, G.G. Byrnes, R.R. Buggage, C.C. Chan: Reply to the letter to the editor "Primary intraocular lymphoma diagnosed by fine needle aspiration biopsy of a subretinal lesion." Retina 22:513, 2002.

Hui Tian M.D. Ph.D

at []

Tian H, Faje AT, Lee SL, Jorgensen TJ. Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways. Neoplasia 2002 Mar-Apr;4(2):171-80

Zhijun Luo Ph.D.


1. Lenz G, Goncalves D, Luo Z, Avruch J, Rodnight R, Neary JT. Related Articles Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf- and MEKK activation in astrocyte cultures. J. Neurochem. 77: 1001-9, 2001.
2. Avruch J, Khokhlatchev2 A, Kyrakis JM, Luo Z, Tzivion G, Vavvas D, and Zhang X-F. Ras activation of the Raf kinase: Tyrosine kinase recruitment of the MAP kinase cascade. Recent Prog. Horm. Res. 56: 127-55, 2001.
3. Lin T, Itani S, Dean DJ, Kurowski TG, Luo ZJ, Yaney GC, and Ruderman NB. Inhibition of insulin signaling and glycogen synthesis by phorbol dibutyrate in rat skeletal muscle. Am. J. Physiol. 281: E8-E15, 2001.
4. Zang M, Waelde CA, Xiang X, Rana A, Wen Rong, and Luo Z. Activation of Raf-1 by EGF and disrupting microtubule integrity through different mechanisms. J. Biol. Chem. 276: 25157-25165, 2001.
5. Zang M, Hayn C, and Luo Z. Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1 . J. Biol. Chem. 277: 4395-4405, 2002.
6. Xiang X, Yuan M, Ruderman N, and Luo Z. 14-3-3 facilitates insulin-stimulated dissociation of IRS-1 from high speed pellet fraction. Mol. End. 16: 552-562, 2002.
7. Xu C. W. and Luo Z. Inactivation of Ras function by allele-specific peptide aptamers. Oncogen. In press.
8. Xiang X, Zang M, Waelde CA, Wen R, and Luo Z. Phosphorylation of S338SYY341 regulates specific interaction between Raf-1 and MEK1. In revision.
9. Luo ZG, Wang Q, Zhou JZ, Wang JB, Luo Z, Liu M, He X, Wynshaw-Boris A, Xiong WC, Lu B, and Mei L. Regulation of AchR clustering by Dishevelled interacting with MuSK and Pak1. Neuron. In press

Jingsheng Tuo

at []

1. Jingsheng Tuo, Catheryne Chen, Xianmin Zeng, Mette Christiansen and Vilhelm A. Bohr. Functional Crosstalk between hOGG1 and the helicase domain of Cockayne syndrome group B protein. DNA Repair 2002, in press
2. Tuo J, Jaruga P, Rodriguez H, Dizdaroglu M, Bohr VA. The cockayne syndrome group B gene product is involved in cellular repair of 8-hydroxyadenine in DNA.. Laboratory of Molecular Gerontology, NIH, LMG, National Institute on Aging, Baltimore, MD 21224. J Biol Chem 2002 Jun 11; [epub ahead of print]
3. Tuo J, Muftuoglu M, Chen C, Jaruga P, Selzer RR, Brosh RM Jr, Rodriguez H, Dizdaroglu M, Bohr VA. The Cockayne Syndrome group B gene product is involved in general genome base excision repair of 8-hydroxyguanine in DNA. Laboratory of Molecular Gerontology, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA. J Biol Chem 2001 Dec 7;276(49):45772-9
4. Muftuoglu M, Selzer R, Tuo J, Brosh RM Jr, Bohr VA. Phenotypic consequences of mutations in the conserved motifs of the putative helicase domain of the human Cockayne syndrome group B gene. Gene. 2002 Jan 23;283(1-2):27-40.
5. Selzer RR, Nyaga S, Tuo J, May A, Muftuoglu M, Christiansen M, Citterio E, Brosh RM Jr, Bohr VA. Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells. Nucleic Acids Res. 2002 Feb 1;30(3):782-93.

Yaohui Xu

at [Yaohui_xu]

1. Xu, Y. and Carr, L.G. Functional characterization of the promoter region of the human m opioid Receptor (hMOR) Gene: identification of activating and inhibitory regions (Cellular and Molecular Biology 47:No.5OL29-OL38, 2001)
2. Xu, Y. and Carr, L.G. Transcriptional regulation of the human m opioid receptor (hMOR) Gene: evidence of positive and negative cis-acting elements in the proximal promoter and presence of a distal promoter (DNA and Cell Biology 20:391-402, 2001)
3. Xu, Y. and Carr, L.G. Binding of Sp1/Sp3 to the proximal promoter of the human m opioid receptor (hMOR) gene is enhanced by DAMGO (GENE 274:119-128, 2001)

Jiang Hong Ye, UMDNJ, New Jersey Medical School


1. Ye JH, Tao L, Ren J, Schaefer R, Krnjevic K, Liu PL, Schiller DA, McArdle JJ. Ethanol potentiation of glycine-induced responses in dissociated neurons of rat ventral tegmental area. J. Pharmacol. Exp. Ther. 296(1):77-83, 2001.
2. Ye JH, Tao L, Zalcman SS. Interleukin-2 modulates N-methyl-D-aspartate receptors of native mesolimbic neurons. Brain Res. 894(2):241-248, 2001.
3. Ye JH, Ponnudurai R, Schaefer R S. Ondansetron, a CNS drug. CNS Drug Review. 7:199-213, 2001.
4. Ye JH, Tao L, Zhu L, Krnjevic’ K, McArdle JJ. Ethanol inhibition of glycine-activated responses in native rat neurons of ventral tegmental area. J Neurophysiol. 86(5):2426-2434, 2001.
5. Tao L and Ye JH. Protein kinase C modulates ethanol inhibition of glycine-activated current in rat neurons from ventral tegmental area. J. Pharmacol Exp Ther. 300(3):967-975,2002
6. Ye JH, Tao L, Zhu L, Krnjevic’ K, McArdle JJ. Decay of ethanol-induced suppression of glycine-activated current of ventral tegmental area neurons. In press. Neuropharmacology.
7. Tao L and Ye JH. Inhibition of glycine receptor function of native neurons by aliphatic n-alcohols. Br. J. Pharmacol. 136, 629-635, 2002.
8. Zhu L, Krnjevic’ K, Jiang ZL, McArdle JJ, Ye JH. Ethanol suppresses fast potentiation of glycine currents by glutamate. In press. J. Pharmacol Exp Ther. 2002.

Tianxin Yang M.D./Ph.D. NIDDK

at [tianxiny]

1. Sun D, Samuelson L, Yang T, Huang Y, Briggs J, Schnermann J. Mediation of tubularglomerular feedback by adenosine: evidence from mice lacking adenosine 1 receptors. Proc Natl Acad Sci U S A. 98:9983-8, 2001
2. Yang T, Forrest S, Stine S, Endo Y, Pasumarthy A, Aller S, Forrest JN, Schnermann J, Briggs J. cDNA cloning of a cyclooxygenase gene and effect of cyclooxygenase inhibition on chloride secretion in rectal gland of the Dogfish shark, Aqualus Acanthias. Am J Physiol in press

Zao C Xu, M.D., Ph.D.  Indiana Uni. School of Medicine


1. Gajendiran M, Ling GY, Pang Z and Xu ZC. (2001) Differential changes of synaptic transmission in spiny neurons of rat neostriatum following transient forebrain ischemia. Neuroscience 105:139-152.
2. Pang, Z., Ling, G. Y., Gajendiran, M. and Xu, Z. C. (2001) Enhanced excitatory synaptic transmission in spiny neurons after unilateral dopamine denervation: an in vivo intracellular recording study. Neurosci. Lett. 308:201-205.
3. Chi, X. X. and Xu, Z. C. (2001) Alterations of single potassium channel activity in CA1 pyramidal neurons after transient forebrain ischemia. Neuroscience 108(4): 535-540.
4. Pang, Z., Ling, G. Y., Gajendiran, M. and Xu, Z. C. (2002) Asymmetrical changes of excitatory synaptic transmission in dopamine denervated striatum after transient forebrain ischemia. Neuroscience 114:317-326.
5. Sun, H. B., Ruan, Y., Xu, Z. C. and Yokota, H. (2002) Involvement of Calcium-Independent Receptor for a-Latrotoxin in brain ischemia. Mol. Brain Res. In press.

Maomi Li


1. Fine S, Lisanti M, Galbiati F, Li M: Elevated expression of caveolin-1 in adenocarcinoma of the colon. Am J Clin Pathol. 115:719-724, 2001
2. Galbiati F, Engelman JA, Volonte D, Zhang XL, Minetti C, Li M, Hou H, Kneitz, Edelmann W, Lisanti MP: Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and T-tubule abnormalities. J Biol Chem. 276:21425-21433, 2001.
3. Li M, Vuolo MA, Weidenheim KM, Minsky LS: Collecting duct carcinoma of the kidney with prominent signet ring features. Modern Pathol. 14:623-628, 2001.
4. Cao QJ, Jones JJ, Li M: Expression of calretinin in human ovary, testis and ovarian sex cord-stromal tumors. Int J Gynecol Pathol. 20:346-352, 2001.
5. Razani B, Engelman JA, Wang XB, Schubert W, Zhang XL, Marks CB, Macaluso F, Russell RG, Li M, Pestell RG, Di Vizio D, Hou H Jr, Knietz B, Lagaud G, Christ GJ, Edelmann W, Lisanti MP: Caveolin-1 null mice are viable, but show evidence of hyper-proliferative and vascular abnormalities. J Biol Chem. 276:38121-38138, 2001.
6. Razani B, Combs, TP, Wang XB, Frank P, Park D, Russell RG, Li M, Tang B, Jelicks LA, Scherer PE, Lisanti MP. Caveolin-1 deficient mice are lean, resistant to diet-induced obesity, and show hyper-triglyceridemia with adipocyte abnormalities. J Biol Chem. 277:8635-8647,2002.
7. Fine SW, Li M. Expression of Calretinin and the a-subunit of inhibin in granular cell tumors. Am J Clin Pathol. In press.

Minsheng Yuan MD. Ph.D. Joslin Diabetes Center


1. Minsheng Yuan, Nicky Konstantopouios, Jongsoon Lee, Lone Hansen, Zhiwei Li, Michael Karin, Steven E. Shoelsan. Reversal of Obesity and Diet induced Insulin Resistance with Salicylates or Targeted Disruption of IKKb. Science 2001; 293: 1673
2. Jason K. Kim, Yoon-Jung Kin, Yan Chen, Irene Moore, Jongsoon Lee, Minsheng Yuan. Zhiwei Li, Michael Karin, Pascale Perret, Steven E. Shoelson, Gerald I Shulman. Prevention of fat-induced insulin resistance by salicylate. Journal of Clinical Investigation (J. C. I) 2001,108:437
3. Xiaoqin Xiang, Minsheng Yuan, Neil Ruderman, Zhijun Luo. 14-3-3 facilitates insulin-stimulated intracellular trafficking of IRS-1. J. Mol. Endocrin. 2002, 16(3):552-562.
4. Rui,Liangyou, Minsheng Yuan, Daniel Frantz, Steven E. Shoelson, Morris F. White. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol. Chem. In Press.

Bao Lu M.D. Children's Hospital, Harvard


1: Fukami S, Watanabe K, Iwata N, Haraoka J, Lu B, Gerard NP, Gerard C, Fraser P, Westaway D, St George-Hyslop P, Saido TC. Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res. 2002 May;43(1):39-56.
2: Castagliuolo I, Morteau O, Keates AC, Valenick L, Wang CC, Zacks J, Lu B, Gerard NP, Pothoulakis C. Protective effects of neurokinin-1 receptor during colitis in mice: role of the epidermal growth factor receptor. Br J Pharmacol. 2002 May;136(2):271-9.
3: Rappert A, Biber K, Nolte C, Lipp M, Schubel A, Lu B, Gerard NP, Gerard C, Boddeke HW, Kettenmann H. Secondary lymphoid tissue chemokine (CCL21) activates CXCR3 to trigger a Cl- current and chemotaxis in murine microglia. J Immunol. 2002 Apr 1;168(7):3221-6.
4: Morteau O, Castagliuolo I, Mykoniatis A, Zacks J, Wlk M, Lu B, Pothoulakis C, Gerard NP, Gerard C. Genetic deficiency in the chemokine receptor CCR1 protects against acute Clostridium difficile toxin A enteritis in mice. Gastroenterology. 2002 Mar;122(3):725-33.
5: Humbles AA, Lu B, Friend DS, Okinaga S, Lora J, Al-Garawi A, Martin TR, Gerard NP, Gerard C. The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1479-84.
6: Morteau O, Lu B, Gerard C, Gerard NP. Hemokinin 1 is a full agonist at the substance P receptor. Nat Immunol. 2001 Dec;2(12):1088. No abstract available.
7: Iwata N, Tsubuki S, Takaki Y, Shirotani K, Lu B, Gerard NP, Gerard C, Hama E, Lee HJ, Saido TC. Metabolic regulation of brain Abeta by neprilysin. Science. 2001 May 25;292(5521):1550-2.
8: Scholzen TE, Steinhoff M, Bonaccorsi P, Klein R, Amadesi S, Geppetti P, Lu B, Gerard NP, Olerud JE, Luger TA, Bunnett NW, Grady EF, Armstrong CA, Ansel JC. Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis. J Immunol. 2001 Jan 15;166(2):1285-91.