徐造成 MD. Ph.D.

徐造成,1982年毕业于广州医学院 ,祖籍安徽。1982年毕业于广州医学院。 1984 年入中山医学院读神经解剖硕士。1986年赴美就读田纳西大学医学院。 1990 年获神经科学博士。 1992年任田纳西大学医学院神经内科助理教授。 1998年任印第安纳大学医学院解剖及细胞生物系副教授。主要科研方向是脑缺血后神经元死亡机制。曾任孟菲斯中国科技协会主席孟菲斯中华文化协会副主席北美华人神经科学协会秘书,1996年应国务院侨办邀请为旅外青年学者团体负责人访华团成员,受江泽民主席接见。

xu

Department of Anatomy and Cell Biology Indiana University School of Medicine 635 Barnhill Drive, MS 207 Indianapolis, IN 46202-5120

E-Mail: zxu@anatomy.iupui.edu Website: http://www.anatomy.iupui.edu/~zxu/

Honors and Awards:

Bachelor of Medicine with Honor, Guangzhou Medical College, 1982
Neuroscience Center of Excellence Predoctoral Fellowship, 1986 - 1989
The First Place, poster competition, Neuroscience Memphis Chapter, 1988
Visiting Professor, The First Military Medical University, P. R. China 1996
Visiting Professor, Guangzhou Medical College, P. R. China 1996
Visiting Professor, Sun Yat-Sen University of Medical Sciences, P. R. China 1998

Publications Papers:

1. Xu, Z. C., Wilson, C.J. and Emson, P.C. (1989) Restoration of the corticostriatal projection in rat neostriatal grafts: electron microscopic analysis. Neuroscience 29(3): 539-550.
2. Xu, Z. C., Wilson, C. J. and Emson, P. C. (1991) Restoration of thalamostriatal projections in rat neostriatal grafts: electron microscopic analysis. J. Comp. Neurol. 303:22-34
3. Xu, Z. C., Wilson, C. J. and Emson, P. C. (1991) Synaptic potentials evoked in spiny neurons in rat neostriatal grafts by cortical and thalamic stimulation. J. Neurophysiol. 65(3):477-493 4. Xu, Z. C., Wilson, C. J. and Emson, P. C. (1992) Morphology of intracellularly stained spiny neurons in rat striatal graft. Neuroscience 48(1): 95-110.
5. Surmeier. D.J., Xu, Z.C., Wilson, C.J., Stefani, A. and Kitai, S.T. (1992) Grafted neostriatal neurons express a late-developing transient potassium current. Neuroscience 48(4): 849-856.
6. Nisenbaum, E. S., Xu, Z. C. and Wilson, C. J. (1994) Contribution of a slowly-inactivating potassium current to the transition to firing of neostriatal spiny projection neurons. J. Neurophysiol. 71:1174-1189
7. Xu, Z. C. and Pulsinelli, W. A. (1994) Responses of CA1 pyramidal neurons in rat hippocampus to transient forebrain ischemia: an in vivo intracellular recording study. Neurosci. Lett. 171:187-191
8. Xu, Z. C. (1995) Neurophysiological changes of spiny neurons in rat neostriatum after transient forebrain ischemia : an in vivo intracellular recording and staining study. Neuroscience 67(4): 823-836.
9. Xi, X. Z. and Xu, Z. C. (1996) The effect of neurobiotin on membrane properties and morphology of intracellularly labeled neurons. J. Neurosci. Meth. 65:27-32.
10. Yao, Z. B., Li, Xiaoda and Xu, Z. C. (1996) GABAergic and asymmetric synapses on somata of GABAergic neurons in CA1 and CA3 regions of rat hippocampus: A quantitative electron microscopic study. Stroke 27(8):1411-1415.
11. Xu, Z. C. and Pulsinelli, W. A. (1996) Neurophysiological changes of CA1 pyramidal neurons following transient forebrain ischemia: An in vivo intracellular recording and staining study. J. Neurophysiol. 76:1689-1698.
12. Gao, T. M. and Xu, Z. C. (1996) In vivo intracellular demonstration of an ischemia-induced postsynaptic potential from CA1 pyramidal neurons in rat hippocampus. Neuroscience 75:665-669. 13. Gao, T. M. and Xu, Z. C. (1996) A novel NMDA receptor-mediated postsynaptic potential evoked from CA1 pyramidal neurons in rat hippocampus after transient forebrain ischemia. Chinese J. Neuroanatomy 12:361-370.
14. Ren, Yubo, Li Xiaoda and Xu, Z. C. (1997) Asymmetrical protection of neostriatal neurons from transient forebrain ischemia by unilateral dopamine depletion. Exp. Neurol. 146:250-257. 15. Gao, T. M., Pulsinelli, W. A. and Xu, Z. C. (1998) Prolonged potentiation and depression of synaptic transmission in CA1 pyramidal neurons induced by lethal ischemia in vivo. Neuroscience 87:371-383.
16. Howard, E. M. Gao, T. M., Pulsinelli, W. A. and Xu, Z. C. (1998) Electrophysiological changes of CA3 neurons and dentate granule cells following transient forebrain ischemia Brain Res. 798:109-118.
17. Gao, T. M., Howard, E. M. and Xu, Z. C. (1998) Transient neurophysiological changes in CA3 neurons and dentate granule cells after severe forebrain ischemia in vivo. J. Neurophysiol. 80:2860-2869.
18. Gao, T. M., Pulsinelli, W. A. and Xu, Z. C. (1999) The changes of membrane properties in CA1 pyramidal neurons after lethal ischemia in vivo. Neuroscience 90:771-780.
19. Xu, Z. C., Gao, T. M. and Ren, Y. (1999) Neurophysiological changes associated with selective neuronal damage in hippocampus following transient forebrain ischemia. Biological Signals and Receptors, 8:294-308
20. Xu, Z. C., Chwang W., Li, X., Chen, X. and He, P. (1999) Gender difference in dopamine concentration and postischemic neuronal damage in neostriatum after unilateral dopamine depletion. Exp. Neurol. 158:182-191.
21. Chi, Xian Xuan and Xu, Z. C. (2000) Increase of potassium current in CA1 neurons of rat hippocampus shortly after transient cerebral ischemia. Neurosci. Lett. 281:5-8.
22. Zeng, Y. S. and Xu, Z. C. (2000) Co-existance of necrosis and apoptosis in rat hippocampus after transient forebrain ischemia. Neuroscience Res. 37:113-125.
23. Feng Wei, Zao C. Xu, Zhican Qu, Jeffrey Milbrandt and Min Zhuo (2000) Role of EGR1 in hippocampal synaptic enhancement induced by tetanic stimulation and amputation. J. Cell Biology, 149:1325-1333.
24. Sun, H. B., Yokota, H., Chi, X. X. and Xu, Z. C. (2000) Differential expression of neurexin mRNA in CA1 and CA3 hippocampal neurons in response to ischemic insult. Mol. Brain Res. 84:146-149.
25. Chi, X. X. and Xu, Z. C. (2000) Differential changes of potassium currents in CA1 neurons after transient forebrain ischemia. J. Neurophysiol. 84:2834-2843.
26. Gajendiran M, Ling GY, Pang Z and Xu ZC. (2001) Differential changes of synaptic transmission in spiny neurons of rat neostriatum following transient forebrain ischemia. Neuroscience 105:139-152.
27. Pang, Z., Ling, G. Y., Gajendiran, M. and Xu, Z. C. (2001) Enhanced excitatory synaptic transmission in spiny neurons after unilateral dopamine denervation: an in vivo intracellular recording study. Neurosci. Lett. 308:201-205.
28. Chi, X. X. and Xu, Z. C. (2001) Alterations of single potassium channel activity in CA1 pyramidal neurons after transient forebrain ischemia. Neuroscience 108(4): 535-540.
29. Sun, H. B., Ruan, Y., Xu, Z. C. and Yokota, H. (2002) Involvement of Calcium-Independent Receptor for ?-Latrotoxin in brain ischemia. Mol. Brain Res. 104:246-249.
30. Pang, Z., Ling, G. Y., Gajendiran, M. and Xu, Z. C. (2002) Asymmetrical changes of excitatory synaptic transmission in dopamine denervated striatum after transient forebrain ischemia. Neuroscience 114:317-326.
31. Pang Z., Deng, P., Ruan, Y. and Xu, Z. C. (2002) Depression of fast excitatory synaptic transmission in large aspiny neurons of neostriatum after transient forebrain ischemia. J. Neurosci. 22: 10948-10957.
32. Kim, B. O., Liu, Y., Ruan, Y., Xu, Z. C., Schantz, L. and He, J. (2003) Neuropathologies in transgenic mice expressing human immunodeficiency virus type 1 Tat protein under the regulation of the astrocite glial fibrillary acidic pretein promoter and doxycycline. Accepted.
33. Ruan, Y. W., Ling, G. Y., Zhang, J. L. and Xu, Z.C. (2003) Multiple forms of postischemic neuronal death in adult striatum and the effects of ischemic severity. Submitted
34. Liu X., Zhang, M., Ruan, Y, Xu, Z.C. and Chen Y. (2003) Specification of developmental expression in mouse embryo by Smad7 promoter. Sunmitted.
35. Deng, P., Pang, Z. and Xu, Z. C. (2003) Developmental changes of potassium currents in large aspiny neurons in the neostriatum. Submitted

Books and chapters:

1. Xu, Z. C. (1984) Atlas of Human Regional Anatomy. Guangzhou Qianjin Educational Publication. 2. Xu, Z.C. and Yang, H. (1985) Human Anatomy and Physiology for High School. Guangzhou Qianjin Educational Publication.
3. Wilson, C. J., Xu, Z. C., Emson P. C. and Feler C. (1990) Anatomical and physiological properties of the cortical and thalamic innervations of neostriatal tissue grafts. Prog. in Brain Res. 82:417-426.
4. Xu, Z. C. (2003) Alterations of synaptic transmission following transient cerebral ischemia. In Neuronal and vascular plasticity: Elucidating basic cellular mechanisms for future therapeutical discovery. Kluwer Academic publishers. (In press)

Graduate students:

1. Qi Hong Zhou, Ph.D. Sep. 1993 - Sep. 1994
2. Eugene Howard, Ph.D. Sep. 1995 - June, 2000
3. Tim Bally, Ph.D. Sept. 1998 - Sept. 2000
4. Yuan Fan, M.S. Sept. 1999 - Oct. 2002
5. Yan Ling Xu, M.S. Sept 1999 - Sept. 2002
6. Ying Zhou, Oct. 2000 - present
7. Yuchun Zhang, Aug. 2002 - present

Postdoctoral trainee:

1. Yubo Ren, M.D. July 1994 ?June 1996 Present position: Research Associate, Merck Inc, Canada. 2. Xin Zheng Xi, M.D. Sept. 1994 - June 1996, Present position: Postdoc, St. Jude Childrens Hospital, Memphis, TN.
3. Zhi Bin Yao, M.D., Ph.D. Sept. 1994 - Feb. 1995, Presnet position: Professor and Chairman, Dept of Anatomy, Sun Yat-Sen Uni Med Sci; Vice Mayor of Zhongshan City, Guangdong, China.
4. Tian Min Gao, M.D., Ph.D. 1995 - 1998, Present position: Professor and Chairman, Dept. of Physiology, The First Military Med Uni, China.
5. Yuan Shan Zeng, M.D., Ph.D. 1998 - 1999 Present position: Professor, Dept of Histology, Associate Dean of School of Basic sciences, Sun Yat-Sen Uni Med Sci, China.
6. Xian Xuan Chi, Ph.D. 1998 - 2000 Present position: Postdoc, Dept of Pharmacology, IUSM, Indianapolis, IN.
7. M. Gajendiran, Ph.D., 1998 - 2000 Present position: Postdoc, Mental Retardation Research Center, UCLA
8. Guang Yi, Ling, M.D., PH.D., 1999 - 2001 Present position: Postdoc, Dept of Neurology, Washington University at St. Louis, MO.
9. Zhi Ping Pang, M.D. 2000 - Present Present position: Postdoc, Dept of Anatomy & Cell Biol, IUSM, Indianapolis, IN.
10. Yiwen Ruan, M.D., Ph.D. 2000 - present Present position: Postdoc, Dept of Anatomy & Cell Biol. IUSM, Indianapolis, IN
11. Ping Deng, M.D., Ph.D. 2001 - present Present position: Postdoc, Dept of Anatomy & Cell Biology, IUSM, Indianapolis, IN.
12. Bende Zou, M.D., Ph.D. 2002 - Present Present position: Postdoc, Dept of Anatomy & Cell Biology, IUSM, Indianapolis, IN.

Research Interests:

Stroke is the third leading cause of death and number one cause of disability in the United States. Neurons in certain regions of the brain (e.g. CA1 pyramidal neurons in hippocampus and medium spiny neurons in neostriatum) are highly vulnerable to transient cerebral ischemia. The mechanisms of such selective cell death following ischemia remain unknown. The long-term goal of this laboratory is to reveal the mechanisms of neuronal damage following cerebral ischemia and provide basis for developing therapeutical interventions. The current projects of this laboratory are investigating the electrophysiological and morphological changes associated with neuronal damage after transient cerebral ischemia in animal models. The research techniques include: intracellular recording and staining in vivo and in vitro; patch-clamped whole-cell or single channel recording in brain slices; quantitative analysis of 3-D reconstructed neurons, light and electron microscopy; immunocytochemistry etc. The results of these studies will improve understanding of the mechanisms of brain damage upon resuscitation following cardiac arrest. Research support: